Chorea, dysarthria, and dystonia in Huntington disease

This man with Huntington disease displays severe generalized chorea, dysarthria, gait impairment, and arm and hand dystonia. While seated he clenches his fists, holds his hands in his lap, and crosses his legs under him in an effort to restrain his involuntary movements. Nevertheless, many choreiform and dystonic movements are apparent. These movements become more apparent during ambulation, which is interrupted by choreiform and dystonic movements of the trunk and legs. Keeping the legs apart affords increased stability. (Contributed by Dr. Joseph Jankovic.)