Epidermal nevus syndrome
The two most frequent phenotypes of epidermal nevus syndrome, linear keratinocytic nevus syndrome and linear sebaceous nevus syndrome, are associated with neurologic manifestations including epilepsy and intellectual disability. Hemimegalencephaly is the most important cerebral anomaly causing neurologic manifestations. CLOVES, SCALP, and Heide’s syndrome are additional syndromes that are part of the neurologic phenotypes. Epidermal nevi are the common denominator in these congenital disorders.
Nov. 14, 2016