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Acromegaly: anterior view of the skull after 25 years of disease

Anterior view of the appearance of the skull (norma facialis) of a 50-year-old woman after 25 years of progressive disease. The upper three cervical vertebrae, which are ankylosed together and to the skull, are seen through the buccal gape. (Gibson case “MC” and Geddes case “EAS 07.") (Source: Geddes AC. Report upon an acromegalic skeleton. J Anat Physiol 1911;45[Pt 3]:256-92. Public domain.)