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Unequal expression of odorant receptors in the olfactory epithelium

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Recent single-cell RNA-sequencing experiments showed that most intact odorant receptors (ORs) are expressed in the olfactory epithelium across a large dynamic range, with only a minority being expressed at very high levels. As measured by single-cell RNA-sequencing, the abundance level of a given odorant receptor in the olfactory epithelium correlates perfectly with the number of olfactory sensory neurons expressing it. The arrow depicts the position of the last odorant receptors plotted. (Source: Kurian SM, Naressi RG, Manoel D, Barwich AS, Malnic B, Saraiva LR. Odor coding in the mammalian olfactory epithelium. Cell Tissue Res 2021;383[1]:445-56. Creative Commons Attribution 4.0 International [CC BY] license, creativecommons.org/licenses/by/4.0.)