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Normal control rat versus the cell drop out and neuronal necrosis within the CA3 regions in a rat treated with domoic acid

Top image (control rat) is a cross-section of the hippocampus of a control rat, showing the granular cell layer (GL) of the dentate gyrus (DG), the molecular layer (ML), and the CA3 and the CA4 regions. Objective x10. Bottom image (domoic acid-treated rat) is a section of the hippocampus of a rat treated with domoic acid, showing cell drop out and neuronal necrosis, particularly within the CA3 regions. Objective x5. Both images are from paraffin sections stained with hematoxylin and eosin. (Source: Pulido 2008. Creative Commons Attribution license. Images have been cropped and placed side by side for comparison by Douglas Lanska MD MS MSPH.)