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Difference between a normal control rat and the vacuolization of pyramidal neurons in the CA3 region of a rat treated with domoic acid

(Left) High magnification of the CA3 region of the hippocampus of a control rat showing good preservation and structural integrity. An electrodense dendritic spine (arrow), terminal axon (At), dendrite, and mitochondria (M) are identified. Scale Bar = x 0.6μm. (Right) High magnification of the CA3 region of the hippocampus of a rat treated by gavage with domoic acid for 64 days, showing loss of structural integrity and marked vacuolar (V) dilatation of dendrites. Scale Bar = x 0.6μm. (Source: Pulido 2008. Creative Commons Attribution license. http://creativecommons.org/licenses/by/3.0.)