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Difference between a normal control monkey and the cell dropout and neuronal necrosis in a monkey treated with domoic acid

Brains of monkeys (Macaca fascicularis, the crab-eating macaque). (Left) Section of the CA3 region of the hippocampus of a control monkey, showing well-preserved pyramidal cells (Py). Blood vessels are seen as white spaces with the endothelial cells at the periphery (arrow), Hematoxylin and eosin staining. Objective x40. (Right) Sections of the hippocampus of a monkey treated with domoic acid, showing cell dropout and neuronal necrosis. Most pyramidal neurons appear with vacuolar cytoplasm (V). Some nuclear pyknosis (arrowhead) is also present. Hematoxylin and eosin staining. Objective x40. (Source: Pulido 2008. Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0.)