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Normal control rat versus the vacuolar cytoplasm within pyramidal neurons in the CA3 region of a rat treated with domoic acid

Top image (control rat) shows the CA3 region with well-preserved pyramidal cells (Py). Blood vessels are seen as white spaces with the endothelial cells at the periphery (arrow). Objective x40. Bottom image (domoic-acid-treated rat) shows the CA3 region with vacuolar cytoplasm (V) within pyramidal neurons (Py). A few shrunken neurons (*) and nuclear pyknosis (arrow) are also present. Objective x40. Both images are from paraffin sections stained with hematoxylin and eosin. (Source: Pulido 2008. Creative Commons Attribution license. http://creativecommons.org/licenses/by/3.0. Images have been cropped and placed side by side for comparison by Douglas Lanska MD MS MSPH.)