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Immune cell products and electrical stimulation synergize to exhaust axons in multiple sclerosis

Nitric oxide, secreted by activated microglia and macrophages, reversibly reduces axonal conduction at low stimulation frequency. Nitric oxide combined with rapid stimulation (perhaps a 128 Hz tuning fork) causes prolonged conduction block. (Contributed by Dr. Anthony Reder.)

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Associated Disorders

  • Optic neuritis
  • Pars planitis (peripheral uveitis)
  • Seizure disorder
  • Transverse myelitis
  • Trigeminal neuralgia
  • Uveitis