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German physician-scientist and Nobel laureate Paul Ehrlich

In 1880, German physician-scientist (and later Nobel laureate) Paul Ehrlich (1854-1915) identified large erythroid precursor cells that he called “megaloblasts” in stained blood smears of patients with pernicious anemia. (Photogravure by A Krauth, 1910. Courtesy of the Wellcome Collection. Creative Commons Attribution 4.0 International license.)

Associated Disorders

  • Alcohol-tobacco amblyopia
  • Cerebral vascular disease
  • Dementia
  • Depression
  • Developmental delay
  • Folate deficiency
  • Gastric resection
  • Glossitis
  • Imerslund-Grasbeck syndrome
  • Malabsorption
  • Megaloblastic anemia
  • Myelopathy
  • Optic neuropathy
  • Pernicious anemia
  • Polyneuropathy
  • Regional enteritis
  • Subacute combined degeneration of the spinal cord