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Reversal of hyperpigmentation in woman with vitamin B12 deficiency and pernicious anemia after initiation of parenteral cyanocobalamin therapy

Resolution of hyperpigmentation on the palms (B1) and dorsum of the hands (B2) 12 weeks after initiation of parenteral cyanocobalamin therapy. (Source: Padhi S, Sarangi R, Ramdas A, et al. Cutaneous hyperpigmentation in megaloblastic anemia: a five year retrospective review. Mediterr J Hematol Infect Dis 2016;8[1]:e2016021. Creative Commons Attribution 2.0 License.)

Associated Disorders

  • Alcohol-tobacco amblyopia
  • Cerebral vascular disease
  • Dementia
  • Depression
  • Developmental delay
  • Folate deficiency
  • Gastric resection
  • Glossitis
  • Imerslund-Grasbeck syndrome
  • Malabsorption
  • Megaloblastic anemia
  • Myelopathy
  • Optic neuropathy
  • Pernicious anemia
  • Polyneuropathy
  • Regional enteritis
  • Subacute combined degeneration of the spinal cord