Headache & Pain
Headache guidelines
Apr. 06, 2021
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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Legend: AdoCbl, adenosyl-Cbl; AdoHcy, adenosylhomocysteine; AdoMet, adenosylmethionine; BHMT, betaine homocysteine methyltransferase; cbl C-G, cobalamin C-G; CBS, cystathionine-beta-synthase; CH2-THF, 5,10-methylenetetrahydrofolate; CH3-THF or MTHF, methyl-tetrahydrofolate; CoIIbl and CoIIIbl indicate different redox states of cobalamin, with Co2+ and Co3+, respectively; DHF, dihydrohydrofolate; DMG, dimethylglycine; Gly, glycine; HC or Hcy, homocysteine; MeCbl, methylcobalamin; Met, methionine; MS, methionine synthase; MSR, methionine synthase reductase; MTHFR, methylenetetrahydrofolate reductase; OHCbl, hydroxotranscobalamin; Ser, serine; TC, transcobalamin; THF, tetrahydrofolate. Note: Minor inconsistencies in the original labeling have been clarified in the revised legend by Dr. Douglas J Lanska. (Source: Huemer M, Diodato D, Schwahn B, et al. Guidelines for diagnosis and management of the cobalamin-related remethylation disorders cblC, cblD, cblE, cblF, cblG, cblJ and MTHFR deficiency. J Inherit Metab Dis 2017;40[1]:21-48. Creative Commons Attribution 4.0 International License, http://creativecommons.org/licenses/by/4.0.)