Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Cellular life cycle of poliovirus

(1) First, poliovirus binds to the cell surface macromolecule CD155, which functions as the receptor. (2) Uncoating the viral RNA is mediated by receptor-dependent destabilization of the virus capsid. (3) Cleavage of the viral protein VPg is performed by a cellular phosphodiesterase, and translation of the viral RNA occurs by a cap-independent (IRES-mediated) mechanism. (4) Proteolytic processing of the viral polyprotein yields mature structural and non-structural proteins. (5) The positive-sense RNA serves as the template for complementary negative-strand synthesis, thereby producing a double-stranded RNA (replicative form, RF). (6) Initiation of many positive strands from a single negative strand produces the partially single-stranded replicative intermediate (RI). (7) The newly synthesized positive-sense RNA molecules can either serve as templates for translation or (8) associate with capsid precursors to undergo encapsidation and induce the maturation cleavage of VP0, which ultimately generates progeny virions. (9) Lysis of the infected cell results in release of infectious progeny virions. (Source: De Jesus NH. Epidemics to eradication: the modern history of poliomyelitis. Virol J 2007;4:70. Creative Commons Attribution [CC BY] license, creativecommons.org/licenses/by/2.0.)

Related Article

Associated Disorders

  • Aseptic meningitis
  • Bulbar polio
  • Bulbospinal polio
  • Infantile paralysis
  • Nonparalytic polio
  • Paralytic polio
  • Polioencephalitis
  • Post-polio progressive muscular atrophy
  • Post-polio syndrome
  • Spinal paralytic polio