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Genomic structure of poliovirus type 1 (Mahoney)

The poliovirus genome consists of a single-stranded, positive-sense polarity RNA molecule, which encodes a single polyprotein. The 5' non-translated region (NTR) harbors two functional domains, the cloverleaf and the internal ribosome entry site (IRES), and is covalently linked to the viral protein VPg. The 3'NTR is polyadenylated. (Source: De Jesus NH. Epidemics to eradication: the modern history of poliomyelitis. Virol J 2007;4:70. Creative Commons Attribution License [CC BY],

Associated Disorders

  • Aseptic meningitis
  • Bulbar polio
  • Bulbospinal polio
  • Infantile paralysis
  • Nonparalytic polio
  • Paralytic polio
  • Polioencephalitis
  • Post-polio progressive muscular atrophy
  • Post-polio syndrome
  • Spinal paralytic polio