General Neurology
Pseudobulbar affect
Jun. 26, 2024
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Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Support: service@medlink.com
Editor: editor@medlink.com
ISSN: 2831-9125
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After binding to cell-surface receptors, poliovirus (160S) undergoes conformational changes of the capsid to the 135S form. The 135S particles are then internalized by an actin- and tyrosine kinase-dependent, but clathrin- and caveolin-independent, mechanism. The release of the viral genome takes place only after internalization from an endocytotic compartment localized within 100-200 nm of the plasma membrane. On release of the RNA genome, the empty capsid (80S) is transported away along microtubules. (Source: Brandenburg B, Lee LY, Lakadamyali M, Rust MJ, Zhuang X, Hogle JM. Imaging poliovirus entry in live cells. PLoS Biol 2007;5[7]:e183. Creative Commons Attribution [CC BY] license, creativecommons.org/licenses/by/2.0.)