Malignant hyperthermia is a hypermetabolic response to potent inhalational agents and/or succinylcholine that can lead to death. Most patients have no signs or symptoms prior to a malignant hyperthermia crisis. However, nonanesthesia-related cases of severe rhabdomyolysis linked to hereditary neuromuscular disorders or RYR1 or CACNA1S mutations are reported in the literature with increasing frequency.
Jun. 07, 2021