Headache & Pain
Dec. 22, 2022
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When the outer pore is blocked by tetrodotoxin (TTX), the sodium ion is trapped in the central cavity and prevents binding of QX-222. QX-222, a lidocaine derivative, is a sodium channel blocker. (Source: Tikhonov DB, Zhorov BS. Predicting structural details of the sodium channel pore basing on animal toxin studies. Front Pharmacol 2018;9:880. See also: Bruhova I, Tikhonov DB, Zhorov BS. Access and binding of local anesthetics in the closed sodium channel. Mol Pharmacol 2008;74:1033-45. Creative Commons Attribution [CC BY] license.)