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Venezuelan equine encephalitis virus virions in tissue specimen fixed using phosphotungstic acid

This negatively stained, transmission electron microscopic image revealed Venezuelan equine encephalitis virus virions in the tissue specimen, which had been fixed using phosphotungstic acid. Phosphotungstic acid is very electron-dense and, due to electrostatic forces of attraction, clings to the capsid surface of each viral particle or virion, thereby highlighting the presence of such pathogens. Venezuelan equine encephalitis is a Togaviridae family member and a member of the genus Alphavirus. Photomicrograph by CDC/Dr. Fred Murphy and Sylvia Whitfield in 1975. (Source: Public Health Image Library, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia. Image 10266. Public domain.)