Neurologic disorders associated with behavioral symptoms

M Justin Coffey MD (

Dr. Coffey of the Menninger Clinic and Geisinger has no relevant financial relationships to disclose.

Amy A Pruitt MD, editor. (

Dr. Pruitt of the University of Pennsylvania School of Medicine has no relevant financial relationships to disclose.

Originally released March 9, 2010; last updated June 9, 2020; expires June 9, 2023


Behavioral disturbances occur in a majority of patients with neurologic disease and are substantial factors determining quality of life for such patients. Most of these difficulties can be treated safely and effectively. Yet behavioral signs and symptoms may go unnoticed or are minimized, incorrectly ascribed to a preexisting psychiatric disorder, or misunderstood as “psychogenic” in origin. Working knowledge of brain-behavior relations helps clinicians understand associated behavioral disturbances as evidence of brain dysfunction. This article relies on descriptive psychopathology to outline common disturbances in various behavioral domains and to consider their diagnostic implications.

Key points


• Behavioral disturbances due to primary neurologic conditions can be distinguished from idiopathic psychiatric disease by applying principles of brain-behavior relationships.


• Functional brain systems, when disturbed, have signature psychopathology.


• Recognizing behavioral disturbances that represent distinct neuropsychiatric syndromes informs diagnostic and treatment considerations.

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