K K Jain MD (Dr. Jain is a consultant in neurology and has no relevant financial relationships to disclose.)
Originally released July 6, 1999; last updated July 9, 2019; expires July 9, 2022

Historical note and terminology

Topiramate is a monosaccharide derivative with a sulfamate functionality. It has multiple putative mechanisms of action. It was developed as an antiepileptic as McN-4853 and showed effectiveness against maximum electroshock in rats with a potency equal to that of phenytoin. Topiramate was commercialized and has been available in the United Kingdom since mid-1995. The United States Food and Drug Administration approved it in 1997.

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