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Folate related one-carbon metabolism

Abbreviations: AHCY: S-adenosylhomocysteine hydrolase; DHF: dihydrofolate; DHFR: dihydrofolate reductase; MS: methionine synthase; MTHFR: methylene tetrahydrofolate reductase; 5-MTHF: 5-methyltetrahydrofolate reductase; THF: tetrahydrofolate; SAH: S-adenosyl-homocysteine; SAM: S-adenosyl-methionine. (Source: van der Windt M, Schoenmakers S, van Rijn B, Galjaard S, Steegers-Theunissen R, van Rossem L. Epidemiology and (patho)physiology of folic acid supplement use in obese women before and during pregnancy. Nutrients 2021;13[2]:331. Creative Commons Attribution [CC BY 4.0] license,