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Myo-inositol biosynthesis and catabolism in mammalian tissues

Most tissues can synthesize myo-inositol following phosphorylation of D-glucose to glucose-6-phosphate with subsequent synthesis of myo-inositol-1-phosphate, which then forms free myo-inositol after dephosphorylation. Myo-inositol can be incorporated into the phosphoinositides cycle, further catabolized to D-glucuronate for renal excretion or converted back to glucose-6-phosphate after a series of enzymatic reactions. Myo-inositol can also be converted to D-chiro-inositol by the enzymatic action of an epimerase. (Source: D’Souza SW, Copp AJ, Greene ND, Glazier JD. Maternal inositol status and neural tube defects: a role for the human yolk sac in embryonic inositol delivery? Adv Nutr 2021;12[1]:212-22. Creative Commons Attribution [CC BY 4.0] license,