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Structural comparison of natural and synthetic polyphenols with classical and non-classical antifolates

Structural comparison of natural (ECG) and synthetic (TMECG) polyphenols with classical (MTX) and non-classical (TQD) antifolates. Abbreviations: ECG: (-)-epicatechin gallate; MTX: methotrexate; TMECG: 3-O-(3,4,5-trimethoxybenzoyl)-(-)- epicatechin; TQD: (R)-6-{[methyl-(3,4,5-trimethoxyphenyl)-amino]methyl}-5,6,7,8-tetrahydroquinazoline- 2,4-diamine. (Source: Sanchez-del-Campo L, Sáez-Ayala M, Chazarra S, Cabezas-Herrera J, Rodríguez-López JN. Binding of natural and synthetic polyphenols to human dihydrofolate reductase. Int J Mol Sci 2009;10[12]:5398-410. Creative Commons Attribution [CC BY 3.0] license, creativecommons.org/licenses/by/3.0.)

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