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Longstanding uncontrolled diabetes mellitus, mildly hypointense lesion in central pons (MRI)

In a 34-year-old female with longstanding uncontrolled diabetes mellitus who presented with quadriparesis and dysphagia, laboratory investigations showed high HbA1c (12.3%), high blood glucose (278 mg/dL), increased serum osmolality, and normal corrected sodium (138 mg/dL). This sagittal T1-weighted image shows a mildly hypointense lesion in the central pons (black circle). (Source: Mir WA, Shrestha DB, Aryal BB, Reddy VK, Yadullahi MA. Central pontine myelinolysis secondary to hyperglycemia in a young patient. Cureus 2021;13[10]:e18495. Creative Commons Attribution license [CC BY],

Associated Disorders

  • Alcoholism
  • Extrapontine myelinolysis
  • Hyperosmolar hyperglycemic state
  • Hypokalemia
  • Malnutrition
  • Osmotic myelinolysis