Sign Up for a Free Account

This is an image preview.
Start a Free Account
to view the full image.

  • Nearly 3,000 illustrations, including video clips of neurologic disorders.

  • Every article is reviewed by our esteemed Editorial Board for accuracy and currency.

  • Full spectrum of neurology in 1,200 comprehensive articles.

  • Listen to MedLink on the go with Audio versions of each article.

Increased signal intensity in the lentiform and caudate nuclei in osmotic demyelination syndrome (DWI)

Diffusion-weighted imaging (DWI) at onset of symptoms in osmotic demyelination syndrome showing symmetrical increased signal intensity in the lentiform and caudate nuclei bilaterally. (Source: Siranart N, Nakaphan P, Viarasilpa V, Anukoolwittaya P, Hemachudha P. Hand knob sign in osmotic demyelinating syndrome. BMC Neurol 2024;24[1]:83. Creative Commons Attribution 4.0 International [CC BY 4.0] license,

Associated Disorders

  • Alcoholism
  • Extrapontine myelinolysis
  • Hyperosmolar hyperglycemic state
  • Hypokalemia
  • Malnutrition
  • Osmotic myelinolysis