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Gastric biopsy in a patient with pernicious anemia

Histopathological examination of the biopsy tissue from body and fundus of a patient with pernicious anemia showed bits of gastric mucosa with areas of atrophy and a reduction in the number of glands, which were replaced by the sheets of chronic inflammatory cells and fibrosis. (A) glandular destruction by lymphocytic infiltrate and fibrosis (H&E stain, 4X); and (B) lymphocytic infiltrate with reactive follicle and severe glandular atrophy (H&E stain, 40X). (Source Ramanathan et al 2017. Creative Commons Attribution License: creativecommons.org/ licenses/by/3.0.)

Associated Disorders

  • Alcohol-tobacco amblyopia
  • Cerebral vascular disease
  • Dementia
  • Depression
  • Developmental delay
  • Folate deficiency
  • Gastric resection
  • Glossitis
  • Imerslund-Grasbeck syndrome
  • Malabsorption
  • Megaloblastic anemia
  • Myelopathy
  • Optic neuropathy
  • Pernicious anemia
  • Polyneuropathy
  • Regional enteritis
  • Subacute combined degeneration of the spinal cord