10393 San Diego Mission Rd, Suite 120
San Diego, CA 92108-2134
Toll Free (U.S. + Canada): 800-452-2400
US Number: +1-619-640-4660
Osborn wave (J wave, ie, notching of the terminal QRS complex) on EKG, which may be seen in hypothermia and severe hypercalcemia. (Source J E Roediger. Courtesy of Wikipedia.)
May. 21, 2021
Becker muscular dystrophy primarily causes progressive skeletal and cardiac muscle degeneration. Common presentations include proximal muscle weakness or myalgias, cardiomyopathy, elevated serum levels of creatine kinase, or, more rarely, malignant hyperthermia after exposure to halothane anesthesia. It is an X-linked recessive neuromuscular disease.
Dec. 07, 2020
General Child Neurology
Apr. 20, 2020
Behavioral & Cognitive Disorders
Familial Alzheimer disease refers to cases where a clear pattern of inheritance within a family is established. Memory loss, particularly declarative memory, is the most important symptom, and is under the strongest genetic influence. Clinical manifestations do not seem to be different from those with the sporadic form of this illness, but early-onset dementia, early myoclonus, and a familial history of dementia should suggest the possibility of a genetic form of Alzheimer disease.
Oct. 28, 2013
Epilepsy & Seizures
Generalized onset tonic-clonic seizures are the most dramatic, severe, and common seizures of syndromes of idiopathic generalized epilepsy. They manifest with violent generalized convulsions, loss of consciousness, and marked autonomic disturbances. They are usually spontaneous, but they may also be provoked by external, mainly photic, stimuli. They are often associated with severe complications that may also be fatal.
Jun. 30, 2021
Neuropharmacology & Neurotherapeutics
Pramipexole is approved for the treatment of early Parkinson disease as monotherapy and as an adjunct to levodopa in advanced stages of the disease. It is also approved for the treatment of restless legs syndrome. Patients with advanced Parkinson disease who have blood pressure problems should use pramipexole with care. Additionally, pramipexole is excreted through the kidneys, and patients with kidney disease may require dosage adjustment.
Sep. 06, 2020
Childhood Degenerative & Metabolic Disorders
Oct. 21, 2020
Angelman syndrome is a neurodevelopmental disorder characterized by intellectual disability, epilepsy, ataxia, and a unique behavioral phenotype. It has generally been felt to result from impaired expression of the maternal allele for the UBE3A gene, which encodes ubiquitin protein ligase E3A. Primary areas of clinical management include the following: seizures, sleep, aspiration risk, GERD, constipation, dental care, vision, obesity, scoliosis, bone density, mobility, communication, behavior, and anxiety.
Apr. 05, 2021