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Response of atrophic glossitis to cobalamin repletion

Clinical photographs of atrophic glossitis in two patients with pernicious anemia before and after treatment with intramuscular injection of 2 mg of vitamin B12 every 2 days for 2 weeks. (A) Atrophic glossitis in a patient with pernicious anemia before treatment. (B) Complete regression of atrophic glossitis after a 2-week course of vitamin B12 injections. (C) Atrophic glossitis in another patient with pernicious anemia before treatment. (D) Complete regression of atrophic glossitis after a 2-week course of vitamin B12 injections. (Source: Wu YH, Hwang MJ, Lee YP, Chiang CP. Atrophic glossitis in pernicious anemia patients can be treated to normal in two weeks by intramuscular injection of vitamin B12. J Dent Sci 2020;15[4]:558-9. Creative Commons [CC BY-NC-ND] License.)

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Associated Disorders

  • Alcohol-tobacco amblyopia
  • Cerebral vascular disease
  • Dementia
  • Depression
  • Developmental delay
  • Folate deficiency
  • Gastric resection
  • Glossitis
  • Imerslund-Grasbeck syndrome
  • Malabsorption
  • Megaloblastic anemia
  • Myelopathy
  • Optic neuropathy
  • Pernicious anemia
  • Polyneuropathy
  • Regional enteritis
  • Subacute combined degeneration of the spinal cord