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Photograph by French photographer and filmmaker Louis Eugène Pirou (1841-1909). Courtesy of the Bibliothèque interuniversitaire de Santé, Paris. Public domain.
Childhood Degenerative & Metabolic Disorders
Dec. 29, 2020
The author reviews the clinical neurotoxicity of the antiarrhythmic agent amiodarone, an amphiphilic drug that forms intralysosomal lipid complexes in
Feb. 16, 2021
Oct. 11, 2020
Neuropharmacology & Neurotherapeutics
Aug. 24, 2021
Anti-IgLON5 disease is characterized by a distinctive sleep disorder with NREM and REM parasomnia, associated with stridor and obstructive sleep apnea. Symptoms of bulbar dysfunction, gait abnormalities, chorea, and cognitive impairment may also be present. It is associated with antibodies in serum and CSF against IgLON5.
Sep. 16, 2019
Sep. 05, 2020
Pathologic laughter and crying can be associated with lesions of the brainstem, along with disturbances at various levels of the central nervous system. It is caused by damage of pathways that arise in the motor areas of the cerebral cortex and descend to the brainstem to inhibit the center for laughter and crying.
Jul. 19, 2021
Femoral neuropathy presents, often acutely, with thigh weakness, numbness, and variable pain. Hip flexion weakness is observed in more proximal lesions. Most femoral neuropathies are caused by iatrogenic compression of the nerve either in the pelvis or beneath the inguinal ligament. Nerve conduction studies and needle EMG are useful for diagnostic and prognostic purposes.
Aug. 20, 2021