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Acromegaly due to ectopic secretion of GHRH

Acromegaly due to ectopic secretion of GHRH by a pancreatic tumor that has metastasized to the liver (left). This has caused pituitary hyperplasia, which is visible on a coronal MRI of the pituitary (right), as well as hyperstimulation of normal somatotroph cells, leading to growth hormone hypersecretion and acromegaly. (Source: Chanson and Salenave 2008. Creative Commons Attribution License 2.0 Generic [CC BY 2.0].)

Associated Disorders

  • Arthritis
  • Cardiomegaly
  • Colon cancer
  • Diabetes mellitus
  • Hypertension
  • Sleep apnea