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Human growth hormone immunostaining of a pituitary adenoma from a 22-year-old man with acromegaly

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(x 200) No immunoreactivity was evident for human growth hormone. Absence of immunostaining for growth hormone is found in a subset of patients with acromegaly (Schroeder JL, Spiotta AM, Fleseriu M, Prayson RA, Hamrahian AH, Weil RJ. Absence of immunostaining for growth hormone in a subset of patients with acromegaly. Pituitary 2014;17(2):103-8). (Source: Gosau M, Vogel C, Moralis A, Proff P, Kleinheinz J, Driemel O. Mandibular prognathism caused by acromegaly - a surgical orthodontic case. Head Face Med 2009;5:16. Creative Commons Attribution 2.0 License, http://creativecommons.org/licenses/by/2.0. Figure edited by Dr. Douglas J Lanska to improve detail and contrast.)