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Neurotoxicology
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Location of tick attachment revealed on MRI (1)
Axial T1-weighted MRI of the brain at the level of the medulla shows a normal appearance of the medulla and the cerebellum. However, on closer inspection, there is a small, isointense area (arrow) seen attached to the skin in the occipital region on the right side. (Source: Sarwar Z, Osborne AF, Shah C, Rathore MH. Neuroimaging in tick paralysis: looking outside the box. Infect Dis Rep 2022;14(6):837-40. Creative Commons Attribution [CC BY] license, creativecommons.org/licenses/by/4.0.)
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Hyperintense signal change of the mammary bodies and periaqueductal gray matter in Wernicke encephalopathy
Axial section of cerebral MRI FLAIR sequence showing hyperintense signal change of the mammary bodies and periaqueductal gray matter in a 66-year-old man with Wernicke encephalopathy complicating prolonged parenteral nutrition. (Source: Slim S, Ayed K, Triki W, et al. Gayet-Wernicke's encephalopathy complicating prolonged parenteral nutrition in patient treated for colonic cancer - a case report. BMC Nutr 2022;8[1]:83. Creative Commons Attribution 4.0 International [CC BY 4.0] license, creativecommons.org/licenses/by/4.0. Image cropped from original.)
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Scheme of complexes of the Pt(NH3)2(OH)+ moiety of carboplatin with the B vitamins
Scheme of complexes of the Pt(NH3)2(OH)+ moiety of carboplatin with the B vitamins, including vitamin B6 (pyridoxine, or its active form pyridoxal 5'-phosphate). The only vitamin with a positive charge is thiamine (vitamin B1). Note that the chemical symbol of platinum is Pt. (Source: Szefler B, Czeleń P, Krawczyk P. The affinity of carboplatin to B-vitamins and nucleobases. Int J Mol Sci 2021;22[7]:3634. Creative Commons Attribution License [CC BY], creativecommons.org/licenses/by/4.0.)